SMARCB1-Deficient Sinonasal Carcinoma–A Case Report and Literature Review
10.3342/kjorl-hns.2023.00479
- Author:
Taegyeong KIM
1
;
Won-Gi HONG
;
Kyung-Ja CHO
;
Myeong Sang YU
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- Publication Type:Case Report
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2024;67(3):171-176
- CountryRepublic of Korea
- Language:KO
-
Abstract:
Switch/sucrose non-fermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)-deficient sinonasal carcinoma is a rare subtype of sinonasal undifferentiated carcinoma (SNUC). Due to the highly aggressive nature of the disease course, it is important to diagnose early and use multimodal treatments in the course of the disease. Two main morphologic patterns are commonly identified under the microscope: plasmacytoid/rhabdoid and basaloid. Furthermore, it demonstrates a total absence of integrase interactor 1 expression upon immunohistochemical staining. Here, we present two cases of SMARCB1-deficient sinonasal carcinoma with contrasting outcomes.
