The Clinical Outcome of Dedifferentiated Liposarcoma
10.4055/jkoa.2024.59.2.111
- Author:
Chang-Bae KONG
1
;
KyuPyung LEE
;
Won-Seok SONG
;
Wan-Hyeong CHO
;
Jae-Soo KOH
;
SangHyun CHO
Author Information
1. Departments of Orthopedic Surgery, Korea Institute of Radiological Medical Sciences, Korea Cancer Center Hospital, Seoul, Korea
- Publication Type:Original Article
- From:The Journal of the Korean Orthopaedic Association
2024;59(2):111-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:Liposarcoma is a mesenchymal neoplasm and comprise 20%–30% of all soft tissue sarcomas, accounting for 1% of all malignancies. This study documented the clinical manifestation and oncological outcomes of dedifferentiated liposarcoma (DDLPS).
Materials and Methods:Eleven patients were diagnosed and treated for DDLPS between January 2013 and December 2020. The age, gender, symptom onset, tumor location, magnetic resonance images, surgical margin, and pathologic diagnosis of the identified cohort were reviewed. The time to local recurrence or metastasis, follow-up duration, and the patients’ final status were analyzed.
Results:The patients comprised seven male and four female patients with a mean age of 59 years (43–73 years). The tumor location was in the thigh in five, inguinal in two, upper arm in two, forearm in one, and popliteal in one. The average tumor diameter was 12 cm (3.5–27.0 cm). At the time of diagnosis, one patient was American Joint Committee on Cancer stage IB, two were II, four were IIIA, and four were IIIB. Local recurrence occurred in four, and distant metastasis occurred in five. The five-year overall survival of patients with DDLPS was 54.5±17.6%, and four died due to disease progression.
Conclusion:Primary DDLPS in the extremities is a subtype of liposarcoma with a poorer prognosis than well-differentiated liposarcoma and myxoid liposarcoma.
