A Study on Cell Mekiated Immunity in Parients with Psoriasis.
- Author:
Kyu Joong AHN
;
Won Suk KIM
- Publication Type:Original Article
- MeSH:
Dermatology;
Dinitrochlorobenzene;
Heredity;
Humans;
Hypersensitivity;
Immunity, Cellular;
Male;
Psoriasis*;
Recurrence;
Seoul
- From:Korean Journal of Dermatology
1981;19(4):397-403
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Psoriasis is common cutaneous disorder involving 0.1~3% Of the general population and is characterized by its marked chronicity and recurrence. A variety of factors, rarging from heredity, environment to abnormal cytodynamics and biochemical perturbation have been implicated but never proved as causative. In recent years, many studies on psoriasis have been reported, showing the presence of certain immunologic abnormalities in patients with psoriasis, and some authors postulated that these immunologic abnormalities, particularly in cell mediated immunity, may play a key role in the pathogenesis of psoriasis. This study was undertaken to evaluate cell mediated immune status of patients with paoriasis using several immunologic parameters. A total of 70 patients (35 were male and 35 were female) between the ages of l:l and 70 years entered this study at the Department of Dermatology of Seoul National University Hospital from January 1980 through September 1980. Peripheral blood T lymphocytes(early and total) were enumerated by E-rosette technique in 55 patients. Delayed cutaneous hypersensitivity reaction was measured in 3O patients using intradermal candidin, trichophytinand PPD. Active sensitization with DNCB was performed in 30 patients.
