Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
- Author:
Tong BU
1
;
Ziyan SUN
;
Yi PAN
;
Xia DENG
;
Guoyue YUAN
Author Information
- Publication Type:Review
- From:Diabetes & Metabolism Journal 2024;48(3):354-372
- CountryRepublic of Korea
- Language:EN
- Abstract: Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus. In recent years, basic and clinical studies have shown that GLP-1 is closely related to lipid metabolism, and it can participate in lipid metabolism by inhibiting fat synthesis, promoting fat differentiation, enhancing cholesterol metabolism, and promoting adipose browning. GLP-1 plays a key role in the occurrence and development of metabolic diseases such as obesity, nonalcoholic fatty liver disease, and atherosclerosis by regulating lipid metabolism. It is expected to become a new target for the treatment of metabolic disorders. The effects of GLP-1 and dual agonists on lipid metabolism also provide a more complete treatment plan for metabolic diseases. This article reviews the recent research progress of GLP-1 in lipid metabolism.
