Diagnostic Performance of On-Site Automatic Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve
- Author:
Doyeon HWANG
1
;
Sang-Hyeon PARK
;
Chang-Wook NAM
;
Joon-Hyung DOH
;
Hyun Kuk KIM
;
Yongcheol KIM
;
Eun Ju CHUN
;
Bon-Kwon KOO
Author Information
- Publication Type:Original Research
- From:Korean Circulation Journal 2024;54(7):382-394
- CountryRepublic of Korea
- Language:EN
-
Abstract:
Background and Objectives:Fractional flow reserve (FFR) is an invasive standard method to identify ischemia-causing coronary artery disease (CAD). With the advancement of technology, FFR can be noninvasively computed from coronary computed tomography angiography (CCTA). Recently, a novel simpler method has been developed to calculate onsite CCTA-derived FFR (CT-FFR) with a commercially available workstation.
Methods:A total of 319 CAD patients who underwent CCTA, invasive coronary angiography, and FFR measurement were included. The primary outcome was the accuracy of CT-FFR for defining myocardial ischemia evaluated with an invasive FFR as a reference. The presence of ischemia was defined as FFR ≤0.80. Anatomical obstructive stenosis was defined as diameter stenosis on CCTA ≥50%, and the diagnostic performance of CT-FFR and CCTA stenosis for ischemia was compared.
Results:Among participants (mean age 64.7±9.4 years, male 77.7%), mean FFR was 0.82±0.10, and 126 (39.5%) patients had an invasive FFR value of ≤0.80. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of CT-FFR were 80.6% (95% confidence interval [CI], 80.5–80.7%), 88.1% (95% CI, 82.4–93.7%), 75.6% (95% CI, 69.6–81.7%), 70.3% (95% CI, 63.1–77.4%), and 90.7% (95% CI, 86.2–95.2%), respectively. CT-FFR had higher diagnostic accuracy (80.6% vs. 59.1%, p<0.001) and discriminant ability (area under the curve from receiver operating characteristic curve 0.86 vs. 0.64, p<0.001), compared with anatomical obstructive stenosis on CCTA.
Conclusions:This novel CT-FFR obtained from an on-site workstation demonstrated clinically acceptable diagnostic performance and provided better diagnostic accuracy and discriminant ability for identifying hemodynamically significant lesions than CCTA alone.
