Can EUS Help to Differentiate Macrocystic Serous Cystadenoma from Mucinous Cystadenoma of the Pancreas by Its Morphologic Characteristics?.
- Author:
Seok Won JUNG
1
;
Sang Soo LEE
;
Kyu Pyo KIM
;
Moon Hee SONG
;
Jimin HAN
;
Jong Cheol KIM
;
Eun Kwang CHOI
;
Young Min JOO
;
Dong Wan SEO
;
Sung Koo LEE
;
Myung Hwan KIM
;
Se Jin JANG
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ssleedr@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Serous cystadenoma;
Mucinous cystadenoma;
Pancreas;
EUS
- MeSH:
Cystadenoma, Mucinous*;
Cystadenoma, Serous*;
Head;
Humans;
Mucins*;
Pancreas*;
Sensitivity and Specificity
- From:Korean Journal of Gastrointestinal Endoscopy
2006;32(2):109-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: A macrocystic variant of a serous cystadenoma (M-SCA) is usually indistinguishable from a mucinous cystadenoma (MCA) as a result of their morphologic similarity on conventional imaging studies. However, a MCA requires a resection due to its malignant potential. The aim of this study was to determine the EUS morphological characteristics of a M-SCA to determine if they could be used to help differentiate it from MCA. METHODS: The clinical and EUS morphologic characteristics were examined in 31 consecutive patients with M-SCA and MCA who underwent surgery. RESULTS: Resected specimens were available from 11 M-SCAs and 20 MCAs. Significant differences were observed with regard to the age and location within the pancreas. On EUS, most of the M-SCA contained microcysts (82%) compared with only 15% of MCA cases, and a lobulated configuration of the cyst was observed more frequently in the M-SCA cases than in the MCA (91% vs. 25%). The combination of microcysts and the lobulated configuration of the cysts had a 100% specificity and positive predictive value for differentiating M-SCA from MCA. CONCLUSIONS: M-SCA tends to occur at a relatively younger age than MCA, and is located mainly in the head of the pancreas. Although there is considerable morphological similarity between M-SCA and MCA on the conventional imaging modalities, the morphological characteristics obtained from EUS including microcysts with a lobulated configuration may help to make a distinction between M-SCA and MCA.
