AMPK Alchemy: Therapeutic Potentials in Allergy, Aging, and Cancer
10.4062/biomolther.2023.222
- Author:
Ram Hari POKHREL
1
;
Suman ACHARYA
;
Sunil MISHRA
;
Ye GU
;
Umar MANZOOR
;
Jeon-Kyung KIM
;
Youngjun PARK
;
Jae-Hoon CHANG
Author Information
1. College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea
- Publication Type:Review
- From:Biomolecules & Therapeutics
2024;32(2):171-182
- CountryRepublic of Korea
- Language:English
-
Abstract:
All cells are equipped with intricate signaling networks to meet the energy demands and respond to the nutrient availability in the body. AMP-activated protein kinase (AMPK) is among the most potent regulators of cellular energy balance. Under ATP -deprived conditions, AMPK phosphorylates substrates and affects various biological processes, such as lipid/glucose metabolism and protein synthesis. These actions further affect the cell growth, death, and functions, altering the cellular outcomes in energy-restricted environments. AMPK plays vital roles in maintaining good health. AMPK dysfunction is observed in various chronic diseases, making it a promising target for preventing and alleviating such diseases. Herein, we highlight the different AMPK functions, especially in allergy, aging, and cancer, to facilitate the development of new therapeutic approaches in the future.
