Allergic rhinitis and hygiene hypothesis
- Author:
Hye Mi JEE
1
;
Minji KIM
;
Hyun Hee KIM
;
Hyo-Bin KIM
;
Yeong-Ho RHA
;
Yang PARK
;
Myongsoon SUNG
;
Youn Ho SHIN
;
Hye Yung YUM
;
Kyung Suk LEE
;
Yong Ju LEE
;
Yoon Hong CHUN
;
Bong Seok CHOI
;
Sun Hee CHOI
;
Yong Mean PARK
;
For the Rhinitis Study Group in the Korean Academy of Pediatric Allergy and Respiratory Diseases
Author Information
- Publication Type:REVIEW
- From:Allergy, Asthma & Respiratory Disease 2024;12(1):3-8
- CountryRepublic of Korea
- Language:English
- Abstract: The hygiene hypothesis, first proposed in 1989, suggested that reduced exposure to infections in early life leads to allergic diseases by the defects in the establishment of immune tolerance. Although many studies provided evidence that some exposure conditions, including family size, antibiotics, probiotics, and viral or bacterial infections, are strongly related to the prevalence of allergic diseases, thereby supporting the hygiene hypothesis, some evidence does not provide acceptable results for the hygiene hypothesis. Further, most studies have focused on patients with asthma or atopic dermatitis, not allergic rhinitis. In this review, we summarize the recent studies for and against the ‘hygiene hypothesis’ and identify causal association with the prevalence of allergic rhinitis.
