Comparative analysis of the CT, clinical, and pathological features of patients with invasive lung adenocarcinoma positive and negative for spread through air spaces
10.13491/j.issn.1004-714X.2024.04.018
- VernacularTitle:浸润性肺腺癌气腔播散的CT、临床与病理特征对照分析
- Author:
Liwei ZHANG
1
;
Guiping YUAN
1
;
Juanjuan FANG
1
;
Minmin TENG
1
;
Dewei SONG
1
;
Bo YU
2
;
Yuanwei SHAO
1
Author Information
1. Department of Imaging Center, The Second People’s Hospital of Dezhou City, Dezhou 253000 China.
2. College of Mathematics and Big Data, Dezhou University, Dezhou 253000 China.
- Publication Type:OriginalArticles
- Keywords:
Invasive lung adenocarcinoma;
Spread through air spaces;
X-ray computed tomography technology;
Pathology
- From:
Chinese Journal of Radiological Health
2024;33(4):459-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of computed tomography (CT), clinical, and pathological features in patients with invasive lung adenocarcinoma positive and negative for spread through air spaces (STAS). Methods A total of 236 patients with invasive lung adenocarcinoma confirmed by surgery and pathology were selected, including 118 patients in STAS-positive group and 118 patients in STAS-negative group. The clinical data, CT signs, and pathological features of the two groups were collected and analyzed. Results There was a correlation between age and the occurrence of STAS. The age of the positive group was higher than that of the negative group. Smoking history and family history of tumor had no correlation with the occurrence of STAS. CT features signs such as nodule type and shape, tumor-lung interface, lobulation sign, spiculation sign, vacuole/cavity, air-bronchogram, pleural indentation sign, vascular changes, mean diameter of tumor, mean diameter of solid component, and the percentage of tumor solid components were significantly different between patients with and without STAS. The incidence of STAS in patients with solid nodules and partial solid nodules was significantly higher than that in patients with ground glass nodules. Multivariate analysis showed that the percentage of tumor solid components, air-bronchogram sign, lobulation sign, and tumor-lung interface were independent risk factors for predicting the occurrence of STAS. Conclusion The clinical data and CT signs of patients with invasive lung adenocarcinoma are related to the occurrence of STAS. CT signs such as the percentage of tumor solid components, air-bronchogram, lobulation sign, and tumor-lung interface are of great significance to STAS prediction. Our findings provide an important basis for selection of personalized clinical treatment plans.
