Application of CT-guided intracavitary/freehand interstitial brachytherapy in radical radiotherapy for cervical cancer
10.13491/j.issn.1004-714X.2024.04.016
- VernacularTitle:CT引导下腔内联合徒手插植在宫颈癌根治性放疗中的应用
- Author:
Yang LI
1
;
Mengyu LIU
1
;
Ping YIN
1
;
Yue LI
1
;
Chenjing ZHU
1
;
Li LIN
1
;
Siyu ZHANG
1
;
Zhihua SUN
1
;
Hanzi XU
1
Author Information
1. Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing 210018 China.
- Publication Type:OriginalArticles
- Keywords:
Cervical cancer;
Three-dimensional intracavitary/free-hand interstitial brachytherapy;
Short-term efficacy
- From:
Chinese Journal of Radiological Health
2024;33(4):447-453
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application of three-dimensional intracavitary/free-hand interstitial brachytherapy technique in radical radiotherapy for cervical cancer. Methods A retrospective study was conducted on the clinical data of patients with cervical cancer who underwent radical radiotherapy using CT-guided three-dimensional intracavitary/free-hand interstitial brachytherapy technique in The Affiliated Cancer Hospital of Nanjing Medical University from April 2019 to September 2021. The short-term efficacy and adverse reactions were analyzed, and the independent predictors affecting short-term efficacy were evaluated by logistic risk regression model. Results A total of 182 patients were included, and all patients successfully completed the treatment. Clinical efficacy assessment performed 3 months after treatment revealed an overall response rate of 90.65%; the incidence of grade 3 and 4 adverse reactions in the lower gastrointestinal tract was 4.4% during treatment. After reclassifying stage IIIC patients according to the International Federation of Gynecology and Obstetrics (FIGO) 2009 staging system and including factors affecting the stage, it was found that the tumor volume before brachytherapy was the main factor affecting the clinical efficacy of patients at this stage (P = 0.004). Conclusion As a key method in radical radiotherapy for cervical cancer, three-dimensional intracavitary/free-hand interstitial brachytherapy technique is safe and effective and can be quickly popularized in primary hospitals beyond regional cancer centers for cervical cancer brachytherapy.
