Role of macrophages in the development and progression of primary biliary cholangitis
- VernacularTitle:巨噬细胞在原发性胆汁性胆管炎发生发展中的作用
- Author:
Zongqi DENG
1
;
Wenlin TAI
Author Information
- Keywords: Primary Biliary Cholangitis; Monocyte; Macrophage; Pathologic Processes
- From: Journal of Clinical Hepatology 2024;40(9):1924-1928
- CountryChina
- Language:Chinese
- Abstract: Primary biliary cholangitis(PBC)is a persistent inflammatory autoimmune liver disease characterized by inflammatory injury and cholestasis in the small intrahepatic bile ducts.At present,the exact pathogenesis of PBC remains unknown,but a consensus has been reached on the fact that PBC is the result of the synergistic effect of various factors.In the cascade of immune and inflammatory reactions associated with PBC,macrophages appear as essential immune cells and actively participate in the damage to bile duct epithelial cells.This article introduces the origin and heterogeneity of macrophages in PBC and reviews the potential role of macrophages in the pathogenesis of PBC.
