Pyroptosis： A new bridge connecting gut microbiota and liver diseases
- VernacularTitle:细胞焦亡： 连接肠道菌群与肝脏疾病的新桥梁
- Author:
Yijie ZHAO
1
;
Lu XIE
1
;
Yating ZHANG
1
;
Guangwei LIU
2
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; Gastrointestinal Microbiome; Pyroptosis; Bile Acids and Salts
- From: Journal of Clinical Hepatology 2024;40(9):1908-1915
- CountryChina
- Language:Chinese
- Abstract: Since the proposal of the concept of the gut-liver axis， a large number of studies have focused on exploring the connection between gut microbiota and liver disease； however， the idea of using pyroptosis as a hub to explore the intrinsic mechanism of gut-liver crosstalk is still in its infancy. This article mainly describes the process by which gut microbiota dysbiosis affects the integrity of mucosal barrier and bile acid metabolism， induces pyroptosis， and thereby affects the development and progression of liver diseases， and it also concludes that gut microbiota dysbiosis affects liver diseases by inducing NLRP3/AIM2/Caspase-1-dependent， Caspase-4/11/GSDMD-dependent， and Caspase-3/GSDME-dependent pyroptosis. In summary， this study aims to provide new ideas and targets for the future diagnosis and treatment of liver diseases by establishing the connection between pyroptosis and intestinal-liver immune crosstalk.
