Regulatory mechanism of exosomes in liver failure and the application value in diagnosis and treatment
- VernacularTitle:外泌体在肝衰竭中的调控机制及其在临床诊疗中的应用价值
- Author:
Hua TONG
1
;
Yue LUO
;
Yadong WANG
Author Information
- Keywords: Liver Failure; Exosomes; Mesenchymal Stem Cells; Hepatocytes
- From: Journal of Clinical Hepatology 2024;40(9):1897-1901
- CountryChina
- Language:Chinese
- Abstract: Exosomes are an important vehicle for mediating material transportation and information transmission between cells,and the exosomes derived from hepatocytes,liver stem cells or extrahepatic mesenchymal stem cells promote the recovery and regeneration of damaged hepatocytes by inhibiting immune inflammatory response,antagonizing against oxidative stress and apoptosis,and inducing autophagy,thereby exerting a protective effect against liver failure.This article reviews the molecular mechanism of exosomes in regulating the pathogenesis of liver failure and its effect on the development,progression,and prognosis of liver failure,in order to assess the potential value of exosomes as a diagnostic marker and a therapeutic target.
