Cloning a new allele form of bovine TNF-alpha.
- Author:
Jongsam AHN
- Publication Type:Original Article
- Keywords:
New allele;
bovine;
TNF-alpha
- MeSH:
*Alleles;
Amino Acid Sequence;
Animals;
Base Sequence;
Cattle;
*Cloning, Molecular;
Gene Library;
Molecular Sequence Data;
Receptors, Antigen, T-Cell, gamma-delta/*physiology;
Sequence Alignment/veterinary;
T-Lymphocytes/immunology/*physiology;
Tumor Necrosis Factor-alpha/chemistry/*genetics/physiology
- From:Journal of Veterinary Science
2001;2(2):139-141
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although little is known on the function of gammadelta T lymphocytes, there is increasing evidence that gammadelta T lymphocytes are early responders and modulators of immune responses against pathogens and cytokines such as IL-2, IL-7, IL-15 and TNF-alpha. To study the role TNF-alpha on gammadelta T lymphocytes, we cloned bovine TNF-alpha. Sequence analysis revealed that a new allele form of bovine TNF-alpha was cloned which has 3 additional nucleotide sequences as well as 3 nucleotide substitutions compared with previously reported bovine TNF-alpha. Further studies are needed to document the functional significance of a new allele form of TNF-alpha in cattle.
