Duloxetine hydrochloride induced syndrome of inappropriate antidiuretic hormone secretion in depression treatment： a case report
10.11886/scjsws20240229002
- VernacularTitle:盐酸度洛西汀治疗抑郁症引发抗利尿激素分泌紊乱综合征1例
- Author:
Shuting YANG
1
;
Ajiao FAN
2
Author Information
1. The First School of Clinical Medical of Lanzhou University， Lanzhou 730000， China
2. The Second Hospital of Lanzhou University， Lanzhou 730030， China
- Publication Type:Journal Article
- Keywords:
Duloxetine hydrochloride;
Depression;
Syndrome of inappropriate antidiuretic hormone secretion
- From:
Sichuan Mental Health
2024;37(4):376-378
- CountryChina
- Language:Chinese
-
Abstract:
Duloxetine hydrochloride，a serotonin-norepinephrine reuptake inhibitor （SNRIs）， is a commonly used antidepressants. Its mechanism of action involves increasing synaptic monoamine neurotransmitters concentration， leading to antidepressant effects. While gastrointestinal reactions and elevated blood pressure are common side effects， duloxetine can rarely induce syndrome of inappropriate antidiuretic hormone secretion （SIADH）. This case report presents a patient with depression who developed SIADH following duloxetine hydrochloride initiation， with the main clinical manifestation being restless thirst and excessive drinking. This case is presented to raise awareness among clinicians of this rare yet potentially serious adverse effect of duloxetine treatment.
