Research progress on the role and mechanism of S100A8/S100A9 in retinal degenerative diseases

Weidi Huang; Caiyang LU; Shuming Chen; Zichun Tang; Xie LI; Shuyan Zheng; Xixuan Huang; Xiao Liu; Zhuo LI

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Research progress on the role and mechanism of S100A8/S100A9 in retinal degenerative diseases

VernacularTitle:S100A8/S100A9在视网膜退行性疾病中的作用及机制研究进展
Author: Weidi HUANG ¹ ; Caiyang LU ¹ ; Shuming CHEN ¹ ; Zichun TANG ¹ ; Xie LI ¹ ; Shuyan ZHENG ¹ ; Xixuan HUANG ¹ ; Xiao LIU ¹ ; Zhuo LI ¹
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1. Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Publication Type:Journal Article
Keywords: damage-associated molecular patterns(DAMP); S100A8/S100A9 protein; diabetic retinopathy; inflammation; retinal degenerative disease
From: International Eye Science 2024;24(10):1610-1614
CountryChina
Language:Chinese
Abstract: The S100 protein family is a key component of damage-associated molecular patterns(DAMP), which play a vital role in regulating inflammation in the body's innate immune response. S100A8/S100A9 proteins play a wide range of antibacterial and anti-infective functions in many diseases, and promote the occurrence and development of the body's immune and inflammatory responses. In various retinal degenerative diseases, S100A8/S100A9 proteins are significantly upregulated at the transcription and translation stages, promoting the activation of inflammatory factors in ocular tissues, the activation and recruitment of immune cells such as macrophages and neutrophils, and the occurrence and development of ocular inflammation. This review aimsat explaining the biological functions of S100A8/S100A9 proteins and their roles and possible mechanisms in retinal degenerative diseases such as diabetic retinopathy, age-related macular degeneration and ischemic retinopathy.