Application of D-galactose in experimental cataract models
10.3980/j.issn.1672-5123.2024.10.07
- VernacularTitle:D-半乳糖在实验性白内障模型中的应用研究
- Author:
Xueqing KONG
1
;
Yongyi SHA
1
;
Chenglong YI
1
;
Minhong XIANG
1
Author Information
1. Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
- Publication Type:Journal Article
- Keywords:
D-galactose;
cataract model;
lens;
pathogenesis;
modeling methods
- From:
International Eye Science
2024;24(10):1558-1562
- CountryChina
- Language:Chinese
-
Abstract:
Cataract is a common eye disease caused by metabolic disorders of the lens, which can lead to visual impairment or blindness. Its occurrence and development are affected by various factors, among which age is the most important factor. At present, drug therapy only has a delaying effect on early cataracts, but surgical treatment is still needed for cataracts that affect vision in the middle and late stages. Therefore, it is crucial to establish an experimental cataract model and explore appropriate drugs for preventing and treating cataracts. D-galactose has been widely used in the study of aging animal models, and is often used in the models of diabetes cataract and age-related cataract. This article elaborates on the pathogenesis, modeling methods, and evaluation criteria for successful modeling of D-galactose-induced cataract models, in order to guide experimental researches related to cataract prevention and treatment.
