Construction and validation of a gastric cancer prognosis model based on disulfidptosis-related LncRNAs
10.19405/j.cnki.issn1000-1492.2024.08.021
- Author:
Liang Feng
1
;
Zhiguo Cao
2
;
Xiaoqi Shi
3
;
Qikun Zhang
1
;
Changyu Chen
1
;
Changjun Yu
1
Author Information
1. Dept of Gastrointestinal Surgery, Anhui Medical University,Hefei 230022
2. Dept of Vascular Surgery ,Affliated Hospital of West Anhui Health Vocational College ,Luan 237010
3. Dept of Radiation Oncology Anhui Medical University,Hefei 230022
- Publication Type:Journal Article
- Keywords:
long non-coding RNA;
cell death;
gastric cancer
- From:
Acta Universitatis Medicinalis Anhui
2024;59(8):1429-1439
- CountryChina
- Language:Chinese
-
Abstract:
Objective :Based on a novel type ofcell death induced by disulfide stress ,known as disulfidptosis ,this study explores the role of long non-coding RNA (LncRNA) in gastric cancer and establishes a prognosis model related to disulfidptosis，providing a new method for assessing the prognosis of gastric cancer treatment．
Methods:Transcriptomic data from gastric cancer and normal tissue samples were obtained from the public database TCGA， and disulfidptosis-related LncRNAs were selected through Pearson analysis and LASSO-Cox regression analysis．A relevant prognostic model for gastric cancer was constructed based on the above LncRNAs and validated by function- al enrichment analysis，tumour microenvironment and immune cell infiltration analysis，drug sensitivity analysis and quantitative reverse transcription PCR(RT-qPCR) .
Results :In this study，400 disulfide death－associated LncRNAs were identified and five of them were screened to construct a prognostic model for assessing the prognosis of gastric cancer patients．The models showed in validation that the survival of the high－risk score group was shorter than that of the low-risk score group(P＜0. 05) ．In addition，the predictive ability of the prognostic model (AUC = 0. 725) was better than that based only on basic characteristics such as age and gender．The expression levels of disulfide death-associated LncRNAs differed between normal and gastric cancer tissues (P＜0. 001) ．
Conclusion:The disulfidptosis-related LncRNA prognosis model developed in this study can effectively assess the prognosis of gastric cancer patients and the tumor microenvironment，providing potential targets and a theoretical basis for new immunotherapeutic strategies for gastric cancer.
- Full text:2024091415412896532双硫死亡相关LncRNA的胃癌预后模型构建与验证_凤亮.pdf
