Relationship between PPARG rs2290449 and the efficacy of combination therapy in sepsis with MODS in Yanbian area
10.19405/j.cnki.issn1000-1492.2024.07.023
- VernacularTitle:PPARG rs2290449位点与延边地区脓毒症伴MODS联合用药疗效的关系
- Author:
Shuyao SUN
1
;
Wanxuan CAI
;
Xia LIU
;
Guang JIN
;
Qingsong CUI
Author Information
1. 延边大学医学院病理与病理生理实验室,延吉 133002
- Keywords:
sepsis;
single nucleotide polymorphism;
drug combinations;
multiple organ dysfunction
- From:
Acta Universitatis Medicinalis Anhui
2024;59(7):1257-1262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the single nucleotide polymorphism of PPARG rs2290449 and the efficacy of combination therapy in sepsis patients with MODS.Methods 382 cases of sepsis with MODS were selected and divided into the effective group and the ineffective group,and a case-control study was conducted.PCR-RFLP and Sequenom MassARRAY were used to detect the genotype and allele frequencies of the loci.Unconditional Logistic regression was used to calculate odds ratio(OR)and 95％confidence interval(CI)to evaluate the efficacy of combination therapy for sepsis with MODS in patients with different genotypes.Re-sults There were G and A alleles in PPARG rs2290449 locus,GG、GA and AA genotype.Non-conditional Logis-tic regression analysis showed that compared with the GG genotype group,the GA genotype group had a significant correlation with the efficacy of combination therapy for sepsis with MODS(OR=0.449,95％CI=0.280-0.722,P=0.001).In the dominant model,there was a significant correlation between the GA+AA genotype and the effi-cacy of combination therapy compared with the GG genotype(OR=2.104,95％CI=1.332-3.321,P=0.001).After adjusting for confounding factors,unconditional Logistic regression analysis showed that compared with the GG genotype,the GA+AA genotype was significantly correlated with the efficacy of combination therapy in sepsis pa-tients with MODS(OR=2.307,95％CI=1.438-3.701,P=0.001).Stratified analysis showed that compared with the population carrying GG genotype,the population carrying GA+AA genotype was significantly correlated with the efficacy of combination therapy in sepsis with MODS in the stratified analysis of age,gender and ethnicity.Conclusion PPARG rs2290449 single nucleotide polymorphism is significantly correlated with the efficacy of com-bination therapy in sepsis patients with MODS in Yanbian area.
