Relationship between PPARG rs2290449 and the efficacy of combination therapy in sepsis with MODS in Yanbian area
10.19405/j.cnki.issn1000-1492.2024.07.023
- Author:
Shuyao Sun
1
;
Wanxuan Cai
1
;
Xia Liu
1
;
Guang Jin
1
;
Qingsong Cui
2
Author Information
1. Laboratory of Pathology and Pathophysiology，School of Medicine，Yanbian University，Yanji 133002
2. Dept of Critical Care Medicine，Yanbian University Hospital，Yanji 133002
- Publication Type:Journal Article
- Keywords:
sepsis;
single nucleotide polymorphism;
drug combinations;
multiple organ dysfunction
- From:
Acta Universitatis Medicinalis Anhui
2024;59(7):1257-1262
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the relationship between the single nucleotide polymorphism of PPARG rs2290449 and the efficacy of combination therapy in sepsis patients with MODS．
Methods :382 cases of sepsis with MODS were selected and divided into the effective group and the ineffective group，and a case-control study was conducted．PCR-RFLP and Sequenom MassARRAY were used to detect the genotype and allele frequencies of the loci． Unconditional Logistic regression was used to calculate odds ratio ( OR) and 95% confidence interval ( CI) to evaluate the efficacy of combination therapy for sepsis with MODS in patients with different genotypes.
Results:There were G and A alleles in PPARG rs2290449 locus，GG、GA and AA genotype．Non-conditional Logis- tic regression analysis showed that compared with the GG genotype group，the GA genotype group had a significant correlation with the efficacy of combination therapy for sepsis with MODS ( OR = 0. 449，95% CI = 0. 280－0. 722，P = 0. 001) ．In the dominant model，there was a significant correlation between the GA + AA genotype and the effi- cacy of combination therapy compared with the GG genotype ( OR = 2. 104，95% CI = 1. 332－3. 321，P = 0. 001) . After adjusting for confounding factors，unconditional Logistic regression analysis showed that compared with the GG genotype，the GA + AA genotype was significantly correlated with the efficacy of combination therapy in sepsis pa- tients with MODS ( OR = 2. 307，95% CI = 1. 438 －3. 701，P = 0. 001 ) ．Stratified analysis showed that compared with the population carrying GG genotype，the population carrying GA + AA genotype was significantly correlated with the efficacy of combination therapy in sepsis with MODS in the stratified analysis of age，gender and ethnicity.
Conclusion :PPARG rs2290449 single nucleotide polymorphism is significantly correlated with the efficacy of com- bination therapy in sepsis patients with MODS in Yanbian area.
- Full text:2024091410535311756PPARG_rs22904...MODS联合用药疗效的关系_孙数耀.pdf
