To explore the causal relationship between rheumatoid arthritis and iron deficiency anemia in European population by two-sample Mendelian randomization
10.19405/j.cnki.issn1000-1492.2024.07.022
- Author:
Yong Wang
1
;
Xiaoling Yao
1
;
Yuzheng Yang
1
;
Yi Ling
1
;
Xueming Yao
1
;
Wukai Ma
1
Author Information
1. Dept of Rheumatology and Immunology，The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine，Guiyang 550001
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
iron deficiency anemia;
two-sample mendelian randomization;
causal association
- From:
Acta Universitatis Medicinalis Anhui
2024;59(7):1251-1256
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the causal relationship between rheumatoid arthritis (RA) and iron deficiency a- nemia (IDA) in European population by two-sample Mendelian randomization analysis．
Methods :The single nu- cleotide polymorphisms ( SNPs ) of RA and IDA were analyzed using public genome-wide association studies ( GWAS) ．The inverse variance weighting method ( IVW) was used as the main analysis method to evaluate the causal effect of RA on IDA．MR-Egger method，weighted median method (WM) ，weighted model method and simple model method were used as regression supplements to evaluate the robustness of sensitivity analysis results．The het- erogeneity function was used to calculate the P-value to test the heterogeneity，and the intercept term intercept was used to test the level pleiotropy.
Results :In the FINNGEN database at the genome-wide level，strong-related SNPs that removed linkage disequilibrium and met the P＜5. 0 × 10 －8 by Mendelian randomization analysis were select- ed．After integrating exposure and outcome data，31 SNPs were obtained as the final effective instrumental variables. IVW showed that RA was a risk factor for IDA (the risk of IDA in RA patients was 1. 064 times higher than that in non-RA patients，OR = 1. 064，95% CI : 1. 028 －1. 103) ．The weighted median method and MR-Egger method re- sults supported the positive correlation between RA and IDA．The intercept value was close to 0，indicating that there was no horizontal pleiotropy between exposure and outcome．The heterogeneity function' s P ＜0. 05 indicated that there was heterogeneity between exposure and outcome，but the random effect model test showed P＜0. 05，indi- cating that even if there was heterogeneity in causality，the overall trend was stable．
Conclusion :RA is a risk factor for IDA，and there is a positive correlation between RA and IDA.
- Full text:2024091410502531728两样本孟德尔随机化探讨欧洲...人群与缺铁性贫血的因果关系_王勇.pdf
