Gastric Cancer Intervention by Traditional Chinese Medicine Regulating Metabolic Reprogramming： A Review
10.13422/j.cnki.syfjx.20241024
- VernacularTitle:中医药调控代谢重编程干预胃癌的研究进展
- Author:
Yanxia GONG
1
;
Min BAI
2
;
Ziyou LIU
2
;
Hanfei CHEN
1
;
Mingkai LYU
1
;
Yongqiang DUAN
1
Author Information
1. School of Traditional Chinese Medicine（TCM）， Ningxia Medical University， Yinchuan 750004， China
2. Gansu University of TCM， Lanzhou 730000， China
- Publication Type:Journal Article
- Keywords:
gastric cancer;
glucose metabolism;
amino acid metabolism;
lipid metabolism;
nucleotide metabolism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(20):290-298
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is a common malignant tumor with complex pathological mechanisms， a low early diagnosis rate， and a high mortality rate. However， surgical treatment， targeted therapy， and chemotherapy have their treatment limitations and toxic side effects. Therefore， exploring the pathogenesis and mechanism of gastric cancer and finding effective treatment methods are important. At present， researches has found that tumor epithelial cells exhibit individual differences in molecular characteristics and exhibit metabolic heterogeneity that affects cell phenotype and function. The interaction between metabolites and cytokines can inhibit the formation of the tumor immune microenvironment and promote malignant progression. Therefore， metabolic reprogramming is regarded as a key feature of tumors and plays an important role in the process of tumor occurrence and development. However， the continuous deterioration of gastric cancer may be closely related to changes in the energy metabolism of cancer cells. Gastric cancer cells may regulate the dysregulation of synthesis or decomposition pathways such as glucose metabolism， amino acid metabolism， lipid metabolism， and nucleotide metabolism and activate associated signaling pathways， key proteins， and genes， leading to proliferation， invasion， and metastasis of cancer cells. In recent years， there has been a close relationship between the effective intervention by traditional Chinese medicine in gastric cancer and the regulation of metabolic reprogramming. There has been some progress in the intervention research on effective ingredients and formulas of traditional Chinese medicine for cancer. This article summarized existing Chinese and foreign literature on how gastric cancer cells affect disease progression by regulating their related metabolic networks， such as glucose metabolism， amino acid metabolism， lipid metabolism， and nucleotide metabolism， as well as how effective ingredients and formulas of traditional Chinese medicine enhance anti-tumor effects through targeted metabolism. It reviewed metabolic reprogramming intervention in gastric cancer， providing a reference for research on metabolic reprogramming regulation by traditional Chinese medicine and new targets and strategies for the treatment and prognosis of gastric cancer.
