Research Progress on Traditional Chinese Medicine Interventions Targeting NF-κB Signaling Pathway to Improve Diabetic Nephropathy
10.13422/j.cnki.syfjx.20241105
- VernacularTitle:中药基于NF-κB信号通路干预改善糖尿病肾病的研究进展
- Author:
Jiangfan GUO
1
;
Xiaomeng WANG
2
;
Qiu'e ZHANG
2
;
Xiaochen LI
2
;
Tonghua LIU
2
;
Lili WU
2
;
Lingling QIN
2
;
Qingsong LI
1
Author Information
1. First Clinical College of Shaanxi University of Chinese Medicine，Xianyang 712046，China
2. Key Laboratory of Health Cultivation of the Ministry of Education， Beijing University of Chinese Medicine，Beijing 100029，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
diabetic nephropathy;
nuclear factor kappa-B （NF-κB）;
signaling pathway;
pathological mechanisms
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(20):241-251
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy （DN） is a chronic microvascular complication in diabetic patients and the main cause of end-stage renal disease （ESRD）. Studies have shown that nuclear factor kappa-B （NF-κB） signaling pathway is involved in the pathological process of DN by activating pathological mechanisms such as inflammation， oxidative stress， fibrosis， apoptosis， autophagy， and pyroptosis. Therefore， blocking the transduction of NF-κB signaling pathway can help prevent and treat DN. Currently， western medical treatment involves strategies such as lowering blood sugar， blood pressure， and lipids， as well as using endothelin receptor antagonists， mineralocorticoid receptor antagonists， aldosterone synthase inhibitors， and other drugs， but they still cannot block the pathological process of DN. Traditional Chinese medicine （TCM） offers a simpler and more cost-effective approach that addresses both the symptoms and underlying causes of DN. Recent research has shown promising results in managing DN with TCM， and NF-κB， as a key factor， plays an important role in the prevention and treatment of DN. This article summarized the research results of TCM based on the NF-κB signaling pathway for the treatment of DN in the past five years. It described a variety of TCM extracts， such as polysaccharides， terpenes， phenols， flavonoids， saponins， and alkaloids， as well as TCM compound prescriptions such as Huaiqihuang granules， Astragalus mongholicus Bunge and Panax notoginseng formula， and Danzhi Jiangtang capsules， which regulated the NF-κB signaling pathway and its upstream and downstream factors to block the pathological process of DN. This inhibition aims to prevent renal pathological damage caused by DN and slow down the deterioration of renal function. The article aims to provide new ideas and references for the research and development of drugs for the prevention and treatment of DN.
