"Spleen-gut-muscle" Model of Chinese Medicine to Explore Effect of Gut Microbiota on COPD with Sarcopenia
10.13422/j.cnki.syfjx.20242291
- VernacularTitle:“脾-肠-肌”的中医模式探讨肠道微生态延缓COPD肌少症的新机制
- Author:
Wang TAO
1
;
Peiyi WANG
2
;
Jie SUN
3
;
Xiaohong ZHANG
1
;
Qin YUAN
1
;
Qiulin ZHU
1
Author Information
1. Guangzhou University of Chinese Medicine，Guangzhou 510000，China
2. The Second Affiliated Hospital of Kunming Medical University，Kunming 650000，China
3. The First Affiliated Hospital of Guangzhou University of Chinese Medicine，Guangzhou 510000，China
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
gut microbiota;
sarcopenia;
spleen-gut-muscle;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(20):186-193
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease （COPD） is susceptible to systemic complications. Especially，sarcopenia is an independent risk factor for COPD patients that can exacerbate respiratory muscle fatigue，lead to a higher risk of falls and fractures，and lower the quality of life. The pathogenesis of sarcopenia involves such aspects as mitochondrial dysfunction，insulin resistance，changes in skeletal muscle fiber types，and an imbalance in protein synthesis and breakdown. As nutrition support and exercise rehabilitation therapy frequently have limited effectiveness，it is urgent to find a way to slow the progression of COPD with sarcopenia. Numerous studies conducted in recent years have discovered a potential link between pulmonary microbiome disorders and the gut microbiota of COPD patients. Furthermore，a wide range of functions of gut microbiota and its metabolites have been demonstrated，such as regulating inflammation and immunity，glucose and lipid metabolism，and mitochondrial function. According to the Zangxiang theory in Chinese medicine， there are intimate connections between the spleen， intestine，and muscle，and gut microbiota may be the most essential part of ameliorating "spleen governing muscle" and increasing muscle mass and strength. This study aims to expound on the effect mechanism of gut microbiota in slowing the progression of COPD with sarcopenia，thereby furnishing novel perspectives and recommendations for forthcoming investigations and therapeutic applications.
