Professor LIU Minru's Medication Rule in Treatment of Polycystic Ovary Syndrome （Intracellular Lipid Membrane Congestion Syndrome）
10.13422/j.cnki.syfjx.20242097
- VernacularTitle:刘敏如教授治疗多囊卵巢综合征胞中脂膜壅塞诸证的用药规律
- Author:
Xinbo HE
1
;
Xiang HU
1
;
Minru LIU
2
;
Fuzhu LI
2
;
Yuhuan HUANG
3
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610032，China
2. Chengdu University of TCM，Chengdu 610075，China
3. Shanghai Daosheng Medical Technology Co. Ltd.，Shanghai 201203，China
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
intracellular lipid membrane congestion syndrome;
data mining;
network pharmacology;
master of traditional Chinese medicine;
LIU Minru
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(20):169-176
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze and sum up the medication rule and the core prescription of Professor LIU Minru in the treatment of polycystic ovary syndrome （intracellular lipid membrane congestion syndrome）and explore the effect mechanism underlying the medication. MethodTwo platforms were used to carry out data mining to analyze the characteristics and rules of Professor LIU's prescriptions for the treatment of this disease. Network pharmacology was used to further clarify active ingredients in the core prescription，and a traditional Chinese medicine-active ingredient-target network was constructed，with the potential mechanism of action analyzed. ResultA total of 321 prescriptions were included in the medical records，involving 178 Chinese medicinals and 28 kinds of formula granules.The Chinese medicinals mainly act on the liver and kidney meridians， whose main tastes were sweetness，pungency，and bitterness and properties were mainly warm，mild，and slightly cold.Commonly used medicine pairs include Dioscoreae Rhizoma-Rehmanniae Radix Praeparata，Chuanxiong Rhizoma-Angelicae Sinensis Radix，Bupleuri Radix-Aurantii Fructus，and Gleditsiae Spina-Curcumae Rhizoma.The commonly used formulas are Xuefu Zhuyutang，Siwugang，Yangjing Zhongyutang，etc. The core prescription is composed of 12 Chinese medicinals such as angelica，white peony，saponaria thorn，and epimedium，containing 74 active ingredients，including quercetin，luteolin，kaempferol，fisetin，and β-sitosterol.A total of 37 key targets were found，involving phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt），mitogen-activated protein kinase （MAPK），Janus protein tyrosine kinase （JAK）/signal transduction and activator of transcription （STAT），and other signaling pathways. ConclusionThe pathogenesis of this disease is complex.Professor LIU adheres to the pathogenesis of "kidney deficiency as the root cause，and phlegm retention as the symptom". Under the guidance of the academic ideology of "kidney Qi as the root，and protecting Yin as the foundation" and "nurturing Yin to support Yang"，she takes into account Yin and Yang in kidney tonic，replenishes and consolidates the essence and blood，and relieves manifestations by dissipating mass， activating blood， and regulating Qi. She has a rigorous thinking in formulating prescriptions. The core prescription has the characteristics of comprehensive regulation by multiple components at multiple targets in multiple pathways.
