Analysis of pathological diagnosis in 703 samples of renal graft biopsy
10.3969/j.issn.1674-7445.2024167
- VernacularTitle:703例次移植肾穿刺活组织检查的病理诊断分析
- Author:
Yuhao TU
1
;
Zhiliang GUO
;
Rula SA
;
Lan ZHU
;
Hui GUO
;
Gang CHEN
Author Information
1. 430030 武汉,华中科技大学同济医学院附属同济医院器官移植研究所教育部器官移植重点实验室国家卫生健康委员会器官移植重点实验室中国医学科学院器官移植重点实验室
- Keywords:
Kidney transplantation;
Puncture;
Biopsy;
Rejection;
Serum creatinine;
Proteinuria;
Rejection;
Infection
- From:
Organ Transplantation
2024;15(5):799-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the occurrence of complications in renal graft biopsy,and to analyze the indications for puncture and types of pathological diagnosis.Methods The data of 703 samples of ultrasound-guided renal graft biopsy from 644 kidney transplant recipients from January 1,2017,to December 31,2022 was retrospectively analyzed.The puncture qualification rate,complications,indicative biopsy indications and pathological diagnosis types were analyzed.The application of surveillance biopsy and pathological diagnosis were also analyzed.Results The qualification rate of renal tissue puncture biopsy was 99.9％,and the complications of puncture bleeding included one sample of perinephric hematoma and one sample of hematuria.Increased serum creatinine(76.8％)and proteinuria(13.8％)were the main indications for puncture,and 48 samples(6.8％)were surveillance biopsy for the assessment of therapeutic effects.A total of 399 samples of pathological diagnosis of rejection,including 293 samples of cellular rejection reaction,60 samples of antibody rejection reaction,and 46 samples of mixed rejection reaction.One hundred and ninety-five samples of recurrence or new-onset kidney disease,mainly including 144 samples of IgA nephropathy and 42 samples of focal segmental glomerulosclerosis.Fifty-seven samples of infection related kidney disease,including 56 samples of BK virus-associated nephropathy(BKVAN).Thirty-one samples of calcineurin inhibitor(CN1)nephrotoxicity injury,including 15 samples of acute CNI nephrotoxicity injury and 16 samples of chronic CNI nephrotoxicity injury.Forty-five samples for other diagnoses.Conclusions The success rate and safety of renal graft biopsy are high,and at present,cellular rejection reaction is still the main pathological diagnosis of indicative biopsy for renal graft.
