Current status and solutions of xenotransplantation matching
10.3969/j.issn.1674-7445.2024160
- VernacularTitle:异种器官移植配型现状及解决思路
- Author:
Shengkun SUN
1
;
Dengke PAN
;
Hongjiang WEI
Author Information
1. 100853 北京,中国人民解放军总医院泌尿外科医学部
- Keywords:
Xenotransplantation;
Organ transplantation;
Matching;
Crossmatch;
Genetically modified pig;
Peripheral blood mononuclear cell;
Endothelial cell;
Rejection
- From:
Organ Transplantation
2024;15(5):752-757
- CountryChina
- Language:Chinese
-
Abstract:
Effective preoperative matching of organ transplantation is essential for the success of organ transplantation.The current methods of preoperative matching for xenotransplantation are derived from human allogeneic organ transplantation.However,these methods are simple and cannot accurately predict whether rejection will occur after transplantation.A noteworthy feature of xenotransplantation lies in the stability of the donor source and the clarity of its genotype,which facilitate convenient sampling and ensure robust repeatability.The multi-link and multi-dimensional preoperative matching is conducive to accurately screening suitable donors and reducing the occurrence of postoperative rejection after xenotransplantation,including making full use of the advantages of donor control in xenotransplantation,expanding tissue level matching methods on the basis of improving traditional cytological matching,paying attention to the role of endothelial cells in matching,and developing organic-level matching methods.Therefore,this article reviews the methods of allogeneic organ transplantation matching,current methods,existing problems and possible breakthroughs of xenotransplantation matching,in order to provide reference for further research on xenotransplantation matching.
