Research progress on traditional Chinese medicine improving polycystic ovary syndrome by regulating NF-κB signaling pathway
- VernacularTitle:中药调控NF-κB信号通路改善多囊卵巢综合征的研究进展
- Author:
Yi ZHANG
1
,
2
;
Ping CHEN
1
;
Yueliang WU
2
;
Miaomiao XUE
2
;
Jianhua SUN
1
Author Information
1. Dept. of Gynaecology and Obstetrics，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China
2. First College of Clinical Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
polycystic ovary syndrome;
NF-κB signaling pathway;
traditional Chinese medicine;
inflammation
- From:
China Pharmacy
2024;35(17):2181-2187
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome （PCOS） is a common endocrine disorder among women of childbearing age. Persistent chronic inflammation can promote the progression of PCOS， thereby causing serious impacts on women’s endocrine metabolism， reproductive function， and psychological status. Nuclear factors- κB （NF- κB） signaling pathway is one of the most classic inflammatory response transduction pathways and is closely related to the pathological process of PCOS. This article summarizes the mechanism of traditional Chinese medicine intervention in PCOS based on the NF-κB signaling pathway， and finds that various monomers of traditional Chinese medicine [flavonoids （naringenin， soy isoflavone， rhamnocitrin， etc.）， alkaloids （berberine， ligustrazine） and terpenoids （artesunate， cryptotanshinone）， glycosides （salidroside， glycyrrhizic acid）] and traditional Chinese medicine compounds [formula for tonifying kidney （Bushen huayu formula， Bushen huatan formula， etc.）， formula for eliminating damp and dissolving phlegm （Cangfu daotan decoction， Xiehe yin， Erchen decoction）， formula for regulating blood circulation and removing stasis （Gexia zhuyu decoction， Huatan tongmai yin）] can alleviate inflammatory response， improve abnormal glucose and lipid metabolism， and enhance ovarian function by inhibiting NF-κB signaling pathway， thus improving PCOS.
