Progress on traditional Chinese medicine in the treatment of bronchial asthma by regulating autophagy
- VernacularTitle:中药通过调控细胞自噬治疗支气管哮喘的研究进展
- Author:
Mengyin LI
1
;
Guihua SONG
2
;
Tingting WANG
1
;
Mingyue REN
1
Author Information
1. College of Pediatrics，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Dept. 2 of Pediatrics，Pediatrics Hospital，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
autophagy;
active components of traditional Chinese medicine;
traditional Chinese medicine
- From:
China Pharmacy
2024;35(17):2158-2164
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma （referred to as “asthma”） is a heterogeneous airway disease characterized by chronic airway inflammation and airway remodeling. Its pathogenesis is complex， the incidence is high and the disease is easy to repeat. Autophagy plays an important regulatory role in improving asthma symptoms. By regulating autophagy-related proteins and signaling pathways， the active components of traditional Chinese medicine （such as flavonoids， anthraquinones， terpenoids） and traditional Chinese medicine compounds （such as Wuhu decoction， Pingchuan granule， Sanzi yangqin decoction） can inhibit airway inflammatory response，reduce airway hyperresponsiveness，and alleviate airway remodeling，thus playing a role in the treatment of asthma. However， most of the current studies are basic studies，and the quality of evidence is not high．In the future，high-quality clinical and basic studies should be further carried out to fully demonstrate the scientific nature of traditional Chinese medicine in the treatment of asthma by regulating autophagy．
