Role of the renin-angiotensin system in myocardial injury in rats with vascular dementia
10.19405/j.cnki.issn1000-1492.2024.07.003
- VernacularTitle:肾素-血管紧张素系统在血管性痴呆大鼠心肌损伤中的作用
- Author:
Jian LI
1
;
Bohan ZHU
;
Peng GAO
;
Ji CHEN
;
Hemu CHEN
;
Xiaoping GAO
Author Information
1. 安徽医科大学第一附属医院康复医学科,合肥 230022
- Keywords:
vascular dementia;
renin-angiotensin system;
myocardial injury;
brain-heart interaction
- From:
Acta Universitatis Medicinalis Anhui
2024;59(7):1123-1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the role of the renin-angiotensin system in myocardial injury induced by experi-mental vascular dementia.Methods Eighteen adult male rats were categorized into a normal group,sham group,and modified 2-vessel occlusion group(model).To assess the myocardial injury caused by experimental vascular dementia,immunostaining was conducted to evaluate the interstitial collagen fraction and myocyte cross-sectional ar-ea.The concentrations of angiotensin Ⅱ(Ang Ⅱ)and angiotensin 1-7(Ang1-7)in the serum,as well as the ex-pression levels of angiotensin converting enzyme(ACE),angiotensin converting enzyme 2(ACE2),Ang Ⅱ,Ang1-7,angiotensin type 1(AT1)receptor,and Mas receptor in the myocardium,were assessed.Results Modified 2-vessel occlusion led to pronounced cognitive dysfunction(P＜0.01)and myocardial injury(P＜0.000 1)when compared to the sham and normal groups.Additionally,modified 2-vessel occlusion induced significant upregulation of the ACE/Ang Ⅱ/AT1 receptor axis(P＜0.01)and downregulation of the ACE2/Ang1-7/Mas axis(P＜0.05)of the renin-angiotensin system in the myocardium.Conclusion Myocardial injury in rats with experimental vascu-lar dementia may be related to dysregulation of the renin-angiotensin system.
