Role of the renin-angiotensin system in myocardial injury in rats with vascular dementia
10.19405/j.cnki.issn1000-1492.2024.07.003
- Author:
Jian Li
1
;
Bohan Zhu
1
;
Peng Gao
1
;
Ji Chen
1
;
Hemu Chen
1
;
Xiaoping Gao
1
Author Information
1. Dept of Rehabilitation Medicine，The First Affiliated Hospital of Anhui Medical University，Hefei 230022
- Publication Type:Journal Article
- Keywords:
vascular dementia;
renin-angiotensin system;
myocardial injury;
brain-heart interaction
- From:
Acta Universitatis Medicinalis Anhui
2024;59(7):1123-1128
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To observe the role of the renin-angiotensin system in myocardial injury induced by experi- mental vascular dementia．
Methods :Eighteen adult male rats were categorized into a normal group，sham group， and modified 2-vessel occlusion group ( model) ．To assess the myocardial injury caused by experimental vascular dementia，immunostaining was conducted to evaluate the interstitial collagen fraction and myocyte cross-sectional ar- ea．The concentrations of angiotensin Ⅱ (Ang Ⅱ ) and angiotensin 1-7 (Ang1-7) in the serum，as well as the ex- pression levels of angiotensin converting enzyme(ACE) ，angiotensin converting enzyme 2 ( ACE2) ，Ang Ⅱ , Ang1- 7，angiotensin type 1 ( AT1) receptor，and Mas receptor in the myocardium，were assessed.
Results :Modified 2- vessel occlusion led to pronounced cognitive dysfunction (P ＜0. 01 ) and myocardial injury (P ＜0. 000 1 ) when compared to the sham and normal groups．Additionally，modified 2-vessel occlusion induced significant upregulation of the ACE / Ang Ⅱ / AT1 receptor axis(P＜0. 01) and downregulation of the ACE2 / Ang1-7 / Mas axis(P＜0. 05) of the renin-angiotensin system in the myocardium．
Conclusion :Myocardial injury in rats with experimental vascu- lar dementia may be related to dysregulation of the renin-angiotensin system.
- Full text:2024091016185159460肾素-血管紧张素系统在血管性痴呆大鼠心肌损伤中的作用_李键.pdf
