Propylthiouracil-induced Diffuse Pulmonary Hemorrhage: A Case Report with the Clinical and Radiologic Findings.
10.3348/jkrs.2007.56.5.479
- Author:
Young Jun CHO
1
;
Joung Sook KIM
;
Ji Young KIM
;
Soo Jeon CHOI
Author Information
1. Department of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Korea. kjsrad@sanggyepaik.ac.kr
- Publication Type:Case Report
- Keywords:
Pulmonary hemorrhage, CT;
Hyperthyroidism;
Vasculitis;
Drug, Side effects
- MeSH:
Adult;
Bronchoalveolar Lavage Fluid;
Cytoplasm;
Female;
Hemoptysis;
Hemorrhage*;
Humans;
Hypertension;
Hyperthyroidism;
Propylthiouracil;
Radiography, Thoracic;
Tomography, X-Ray Computed;
Vasculitis
- From:Journal of the Korean Radiological Society
2007;56(5):479-481
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Propylthiouracil (PTU) is a drug that's used to manage hyperthyroidism and it can, on rare occasions, induce antineutrophil cytoplasmic antibody-associated vasculitis that involves multiple organ systems and it can also cause extremely rare isolated or diffuse pulmonary hemorrhage. We report here on a case of a patient who developed diffuse pulmonary hemorrhage after she had been taking PTU for five years. The patient is a 33-year-old woman who presented with hemoptysis. Simple chest radiographs and the chest CT showed bilateral ground-glass opacity, consolidation and pulmonary arterial hypertension. The bronchoalveolar lavage fluid revealed alveolar hemorrhage. The laboratory values showed increased perinuclear-antineutrophil cytoplasmic antibody (p-ANCA) and anti-peroxidase antibody titers.
