Research progress of microneedle in promoting wound healing

VernacularTitle:微针在促伤口愈合中应用的研究进展
Author: Yating CHEN ¹ ; Yue WU ; Zixian DENG ; Yunqing ZHANG ; Shixun2 WU ; Bingzheng SHEN
Author Information

1. 武汉大学人民医院药学部, 武汉 430060
Publication Type:Journal Article
Keywords: microneedles / drug delivery / wound healing / antibacterial / anti-inflammatory
From: Journal of China Pharmaceutical University 2024;55(4):557-564
CountryChina
Language:Chinese
Abstract: Abstract: The healing process of skin wounds caused by severe mechanical trauma and chronic diseases (e.g., diabetic foot ulcers) is often accompanied by tissue injury, microbial infection, intense inflammatory reactions, hypertrophic scars, and other complications. Microneedles have been widely used to facilitate wound healing in recent years. According to their different modes of action, microneedle formulation can be categorized into five types: solid microneedles, hollow microneedles, coated microneedles, soluble microneedles, and hydrogel microneedles. This paper reviews the preparation methods and characteristics of microneedles, and summarizes their roles in hemostasis, bacteriostasis, anti-inflammation, enhancement of collagen deposition, and angiogenesis, in the hope of providing some reference for future research and development.