Research progress of nanocrystalline drugs in different drug delivery systems
10.11665/j.issn.1000-5048.2023111404
- VernacularTitle:纳米晶体药物在不同给药系统中的研究进展
- Author:
Yaoting HAO
1
;
Yanhui LI
;
Huicong ZHANG
;
Jingwen LIU
;
Chunlei LI
Author Information
1. 河北医科大学机构药学院, 石家庄 050031
- Publication Type:Journal Article
- Keywords:
nanocrystal / route of administration / stabilizer / pharmacokinetics / bioavailability
- From:
Journal of China Pharmaceutical University
2024;55(4):548-556
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Nanocrystal technology changes the solubility and dissolution rate of insoluble drugs by reducing the particle size to the nanometer level. This technology is not limited by carrier materials and encapsulation rate. It is suitable for a variety of drug delivery routes and easy for industrial production. It has gradually become a cutting-edge hot technology in the international pharmaceutical field to improve the absorption of insoluble drugs and improve their bioavailability. This article introduces the influencing factors and challenges of nanocrystal drugs (NC) in parenteral, ocular, transdermal and pulmonary administration, and focuses on nanocrystal drugs that have been marketed or are still in the preclinical or clinical trial stages of these delivery systems, in order to provide some insight for the further development of poorly soluble drug nanocrystal preparations.
