Research progress of pH-responsive drug delivery systems in cancer immunotherapy
10.11665/j.issn.1000-5048.2024011902
- VernacularTitle:pH响应型药物递送系统在肿瘤免疫治疗领域的研究进展
- Author:
Shihao WANG
1
;
Lifeng LIU
;
Yang DING
;
Suxin LI
Author Information
1. 中国药科大学药学院药剂系, 南京 211198
- Publication Type:Journal Article
- Keywords:
tumor / immunotherapy / drug delivery system / pH-responsive / targeted delivery
- From:
Journal of China Pharmaceutical University
2024;55(4):522-529
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Cancer immunotherapy, which is an attractive strategy harnessing the host's own immune system to remove tumor cells, has been widely used in clinical practice, yet with low response rate and immune-related adverse events. Unlike traditional chemotherapy, the targets of immunotherapy exhibit high spatial heterogeneity and are distributed in different cell types or secondary organelles, resulting in off-target and on-target toxicity, which greatly reduces the efficacy and safety of treatment. Due to the altered metabolic level, tumor tissues often display a lower pH than normal tissues. In addition, the endocytosis pathway is accompanied by continuous pumping of protons. Therefore, the variation of environmental pH values could serve as an ideal stimulus for precise drug delivery and release. In recent years, pH-responsive materials (e.g., polymers, biomacromolecules, lipid nanoparticles, biofilm, inorganic nanoparticles, and metal-organic frameworks) have been widely investigated in the field of cancer immunotherapy. This paper summarizes recent strategies of pH-responsive drug delivery systems based on different types of carriers, aiming to provide some reference for the design of next generation of tumor-targeting formulations in cancer immunotherapy.
