Determination of non-steroidal anti-inflammatory drugs in the environmental water samples by a polyvinylimide-modified magnetic nanoparticles-based solid phase extraction coupled with high-performance liquid chromatography
0.11665/j.issn.1000-5048.2023081802
- VernacularTitle:基于聚乙烯亚胺修饰磁性纳米粒的分散固相萃取/高效液相色谱法测定水中非甾体抗炎药
- Author:
Xiaohang TANG
1
;
Huilin SONG
;
Liying YAO
;
Guowen QIN
;
Xingchen WANG
;
Wenyuan LIU
;
Shunli JI
Author Information
1. 东台市人民医院药学科
- Publication Type:Journal Article
- Keywords:
non-steroidal anti-inflammatory drugs / polyvinylimide / magnetic solid phase extraction / nanoparticles / high performance liquid chromatography
- From:
Journal of China Pharmaceutical University
2024;55(4):485-492
- CountryChina
- Language:Chinese
-
Abstract:
The long-term presence of non-steroidal anti-inflammatory drugs (NSAIDs) in the environmental water samples not only affects the life safety of aquatic organisms and disturbs the ecoenvironment, but also poses a serious threat to human health. In this study, amino-functionalized Fe3O4 nanoparticles (Fe3O4-NH2) were firstly prepared by solvothermal method. Subsequently, polyethyleneimine (PEI) with a branched chain structure was successfully grafted onto Fe3O4 nanoparticles by Schiff base reaction in aqueous solution at room temperature using glutaraldehyde as a cross-linking agent, and a recyclable PEI-grafted magnetic nano-sorbent (Fe3O4@PEI) was synthesized and applied for the detection of NSAIDs in the environmental water samples. The compositional properties of Fe3O4@PEI were investigated by different characterization methods and the parameters affecting the extraction of NSAIDs were optimized. Due to high adsorption of Fe3O4@PEI for NSAIDs, the quantitative analysis of four NSAIDs in the environmental water samples, ketoprofen, naproxen, diclofenac and tolfenamic acid, was performed in combination with high-performance liquid chromatography. A good linear relationship between the chromatographic peak area and concentration was observed in the range of 1−500 µg/mL. The recoveries of the samples at three different spiked levels ranged from 85.6% to 107.8%; the intra-day precision was less than 7.8% (n=6); and the inter-day precision was less than 9.5% (n=3). The method is simple, rapid, accurate and reliable, and can be used for the analysis of NSAIDs in the environmental water samples．
