Role and Mechanism of Chinese Herbal Saponins in Ameliorating Metabolism-associated Fatty Liver Disease： A Review
10.13422/j.cnki.syfjx.20241103
- VernacularTitle:中药皂苷改善代谢相关脂肪性肝病的作用及机制研究进展
- Author:
Linlin WANG
1
;
Zhengwang ZHU
1
;
Jinghan ZHAO
1
;
Pingsheng ZHU
1
;
Mingsan MIAO
1
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
Chinese herbal saponins;
metabolism-associated fatty liver disease;
lipid metabolism;
oxidative stress;
intestinal flora
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(19):273-281
- CountryChina
- Language:Chinese
-
Abstract:
Saponins are widely found in various Chinese medicines such as Ginseng Radix et Rhizoma， Notoginseng Radix et Rhizoma， and Bupleuri Radix. They possess multiple biological activities， including anti-inflammatory， antioxidant， antitumor， hepatoprotective， lipid-lowering， and hypoglycemic effects. They play an important role in the prevention and treatment of diseases such as acute lung injury， hyperlipidemia， and diabetic cardiovascular complications， and hold significant research potential and value. Metabolism-related fatty liver disease is a prevalent chronic liver disease characterized by excessive lipid accumulation in hepatocytes. According to the "multiple hit" theory， its occurrence is the result of systemic homeostasis disorder， influenced by abnormal lipid metabolism， oxidative stress， inflammation， insulin resistance， mitochondrial dysfunction， and intestinal microbiota. However， there is currently no effective treatment available in clinical practice. Recent studies have found that Chinese herbal saponins can alleviate metabolism-related fatty liver disease through various pathways， including regulating abnormal lipid metabolism， inhibiting inflammatory responses， alleviating oxidative stress， reducing insulin resistance， improving mitochondrial dysfunction， modulating intestinal flora， inhibiting hepatocyte programmed death， regulating liver autophagy， and correcting immune imbalances. Therefore， this review summarized the pharmacological effects and related mechanisms of Chinese herbal saponins in improving metabolism-related fatty liver disease in recent years， aiming to provide a theoretical reference for the clinical application and experimental research of Chinese herbal saponins in the prevention and treatment of metabolism-related fatty liver disease.
