Traditional Chinese Medicine Regulates Gut Microbiota in Treatment of Thyroid Diseases via Gut-thyroid Axis： A Review
10.13422/j.cnki.syfjx.20242198
- VernacularTitle:基于“肠-甲状腺”轴探讨中医药调节肠道菌群治疗甲状腺疾病的研究进展
- Author:
Shanshan LI
1
;
Dandan WEI
2
;
Yu FU
2
;
Ping WANG
2
;
Hui WANG
3
;
Shuxun YAN
2
Author Information
1. The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450000；China
2. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
3. Henan University of Chinese Medicine，Zhengzhou 450000，China
- Publication Type:Journal Article
- Keywords:
thyroid diseases;
gut-thyroid axis;
gut microbiota;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(19):254-262
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid diseases are common endocrine disorders with high incidence. The diseases are closely related to genetic factors， immune system disorders， and hormone levels. Although modern medical therapies have achieved certain therapeutic effects， the side effects have affected clinical treatment. In recent years， studies have proven that gut microbiota is a key factor affecting thyroid diseases， and increasing studies have referred to the bidirectional information interaction system between the gut and thyroid as the gut-thyroid axis. This study adopts the meridian-collateral theory and the visceral manifestation theory of traditional Chinese medicine （TCM） to explain the functions， physiological characteristics， and pathological mechanisms of the gut and thyroid. Furthermore， this paper clarifies the mechanism of gut microbiota in modulating thyroid homeostasis by inducing inflammation and altering thyroid hormone metabolism from the perspective of molecular biology， clarifying the rationality of the gut-thyroid axis from the perspectives of TCM and Western medicine. Meanwhile， under the guidance of the gut-thyroid axis， increasing studies have been carried out regarding the application of TCM in regulating gut microbiota in the treatment of thyroid diseases. Both the active component emodin and compound prescription Yiqi Huatan Huoxue prescription of Chinese medicine can treat thyroid diseases by regulating the abundance and diversity of gut microbiota and improving the intestinal mucosal barrier. However， the systematic review of the research on TCM treatment of thyroid diseases by regulating gut microbiota remains to be conducted. This study expounds the gut-thyroid axis from both TCM and Western medicine and reviews the research progress in the TCM treatment of thyroid diseases by regulating gut microbiota， aiming to give new insights into the prevention and treatment of thyroid diseases with TCM.
