Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs.
10.4142/jvs.2013.14.2.215
- Author:
Korakot NGANVONGPANIT
1
;
Burin BOONSRI
;
Thatdanai SRIPRATAK
;
Patsanan MARKMEE
Author Information
1. Animal Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand. korakot.n@cmu.ac.th
- Publication Type:Original Article
- Keywords:
biomarker;
dog;
joint surgery;
osteoarthritis;
sodium hyaluronate
- MeSH:
Animals;
Blood Chemical Analysis/veterinary;
Chondroitin Sulfates/metabolism;
*Dogs;
Dose-Response Relationship, Drug;
Enzyme-Linked Immunosorbent Assay/veterinary;
Female;
Hyaluronic Acid/*administration & dosage/metabolism;
Injections, Intra-Articular/veterinary;
Male;
Osteoarthritis, Knee/drug therapy/prevention & control/*veterinary;
Stifle/*surgery;
Viscosupplements/*administration & dosage
- From:Journal of Veterinary Science
2013;14(2):215-222
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thirty-one dogs with patellar luxation (grades 2 and 3) were categorized into three groups. Group 1 (G.1; n = 12) had sodium hyaluronate (SHA) intra-articularly injected into the stifle joint that received surgery. Group 2 (G.2; n = 10) received SHA twice: first after surgery and then 1 week later. Group 3 (G.3; n = 9) served as a control, without injection. Blood was collected before injection and then once a week for 4 weeks after injection for evaluation of chondroitin sulfate (CS-WF6) and hyaluronan (HA). The results revealed significantly (p < 0.05) improved clinical scores by the end of week 4 in G.1 and G.2 relative to G.3; however, there was no significant difference between G.1 and G.2. There was a significant decrease (p < 0.05) in serum CS-WF6 levels beginning at week 2 in G.1 and G.2. At weeks 3 and 4, serum HA in G.1 and G.2 differed from that in G.3 (p < 0.05). No significant difference (p > 0.05) was observed in serum biomarkers between G.1 and G.2. In conclusion, intra-articular injection with SHA after joint surgery may improve homeostasis of the joint, retarding the process of OA.
