Prevention and Treatment of Knee Osteoarthritis by Targeted Mitochondrial Quality Control with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20240622
- VernacularTitle:中医药靶向MQC防治膝骨关节炎的研究进展
- Author:
Jixin CHEN
1
;
Qinxin ZHOU
2
;
Weijie YU
1
;
Tianci GUO
1
;
Dongdong CAO
1
;
Puyu NIU
1
;
Yuntian YE
1
;
Aifeng LIU
1
Author Information
1. National Clinical Research Center for Chinese Medicine Acupuncture， First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM）， Tianjin 300381， China
2. Shaoxing TCM Hospital， Shaoxing 312000， China
- Publication Type:Journal Article
- Keywords:
knee osteoarthritis;
mitochondrial quality control;
traditional Chinese medicine;
multi-faceted;
multi-pathway;
multi-target;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(19):245-253
- CountryChina
- Language:Chinese
-
Abstract:
Knee osteoarthritis （KOA） is a common degenerative joint disease characterized primarily by the degeneration and damage of knee joint cartilage， accompanied by osteophyte formation and inflammation. In recent years， the prevalence of KOA has been increasing globally， significantly impacting the quality of life patients. However， the pathogenesis of KOA remains not fully understood， and current treatment methods are limited. Therefore， finding new therapeutic strategies is a research hotspot. Previous studies have found that the onset of KOA is related to abnormal mitochondrial regulation. Mitochondria， functioning as secondary messengers， play crucial roles in cellular respiration， reactive oxygen species （ROS） generation， and adenosine triphosphate （ATP） production through oxidative phosphorylation. Mitochondrial quality control is a pivotal mechanism for maintaining the morphology， quantity， and quality of mitochondria. The connection between mitochondrial quality control and the pathogenesis of KOA involves several factors， such as mitochondrial oxidative stress， mitophagy， imbalances in mitochondrial biogenesis， abnormal mitochondrial dynamics （fission and fusion）， and dysregulation of calcium ions. Metabolic abnormalities in the body lead to mitochondrial structural damage， which in turn contributes to the onset and progression of KOA. Traditional Chinese medicine （TCM） has made some progress in intervening in mitochondrial quality control， employing multi-faceted， multi-pathway， and multi-target strategies to treat KOA. Several studies have shown that mitochondrial quality control may be one of the therapeutic targets of TCM in treating KOA. However， there is currently a lack of comprehensive reviews summarizing the TCM interventions in mitochondrial quality control for treating KOA. This paper systematically reviewed the research progress in TCM treatment of KOA based on five aspects of mitochondrial quality control， aiming to provide a theoretical basis for the clinical prevention and treatment of KOA.
