Research Progress on Signaling Pathways Related to Treatment of Diabetic Cognitive Dysfunction with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20231717
- VernacularTitle:中药治疗糖尿病认知功能障碍相关信号通路研究进展
- Author:
Xinrui LI
1
;
Yuqing WANG
1
;
Ming SU
1
;
Xinru SUN
1
;
Hui ZHANG
1
;
Kangning XIAO
1
;
Shanxin LIU
1
;
Xinjun ZHANG
1
Author Information
1. Shandong Academy of Chinese Medicine， Jinan 250014，China
- Publication Type:Review
- Keywords:
diabetes;
cognitive dysfunction;
traditional Chinese medicine;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(19):225-232
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cognitive dysfunction （DCD） is one of the complications of diabetes， which is characterized by impaired brain structure and progressively decreased learning and memory ability. With the increasing incidence of diabetes worldwide， DCD has become a serious medical and social problem. However， its pathophysiological mechanisms are not well understood. The occurrence and development of DCD involve multiple pathological links and mechanisms， and the prevention and treatment require multi-link and multi-target therapeutic measures. At present， there is no specific drug to prevent or improve DCD. Hypoglycemic drugs such as metformin and vigagliptin or anti-dementia drug including Donepezil are commonly used in clinical treatment to delay the occurrence and progression of cognitive dysfunction， but these drugs have a single target and obvious side effects. Traditional Chinese medicine has a long history in the prevention and treatment of diabetes and central cognitive diseases， and it has many unique advantages such as multiple components， multiple targets， side effects， and low price. A large number of studies have confirmed that traditional Chinese medicine has a significant prevention and treatment effect on DCD， which can improve insulin resistance， synaptic dysfunction， inflammation， oxidative stress， endoplasmic reticulum stress， and neuronal apoptosis by regulating phosphatidylin-ositol 3-kinase （PI3K）/protein kinase B （Akt）， advanced glycation end products （AGEs）/advanced glycation end products receptor （RAGE）/nuclear transcription factor-κB （NF-κB）， NOD-like receptor thermal protein domain associated protein 3 （NLRP3） inflammasome， and endoplasmic reticulum stress and nuclear factor E2 related factor 2 （Nrf2）/antioxidant response element （ARE） signaling pathways. This article reviewed the effects and related mechanisms of traditional Chinese medicine on DCD in recent years， so as to provide a reference for the prevention and treatment of DCD by traditional Chinese medicine.
