Research Progress of Traditional Chinese Medicine Compounds in Prevention and Treatment of Colorectal Adenoma： A Review
10.13422/j.cnki.syfjx.20240921
- VernacularTitle:中药复方防治结直肠腺瘤研究进展
- Author:
Meng SHEN
1
;
Ye ZHANG
1
;
Kai CHEN
2
;
Yuquan TAO
1
;
Minmin FAN
1
;
Mingxin NI
1
;
Liu LI
1
;
Haibo CHENG
1
Author Information
1. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention Treatment of Tumor， First School of Clinical Medicine， Nanjing University of Chinese Medicine， Nanjing 210023， China
2. The First Affiliated Hospital of Soochow University， Suzhou 215006， China
- Publication Type:Journal Article
- Keywords:
colorectal adenoma;
traditional Chinese medicine （TCM） compounds;
clinical research;
mechanism research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(19):64-72
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal adenoma is a benign tumor originating from the mucosal glandular epithelium of the colorectum and belongs to the category of intraepithelial neoplasia. Its etiology and pathogenesis are not completely clear， and some patients have genetic factors. In recent years， with the improvement in living standards， the incidence of colorectal adenoma has gradually increased due to high-fat diets， intestinal flora disorder， and emotional disturbance. As one of the precancerous lesions of colorectal cancer， colorectal adenoma is increasingly threatening human health. Surgical resection is the most direct and effective method for the treatment of colorectal adenoma， but some patients with colorectal adenoma have the possibility of recurrence after resection. At present， there is still a lack of effective prevention and treatment measures for the recurrence of colorectal adenoma. Traditional Chinese medicine （TCM） plays a unique advantage in improving the clinical symptoms of patients with colorectal adenoma and preventing postoperative recurrence and carcinogenesis. Therefore， this review summarized the clinical research and mechanism of TCM compounds in the prevention and treatment of colorectal adenoma in recent years. The clinical study on the prevention and treatment of colorectal adenoma by TCM compounds can be divided into internal treatment， external treatment， and internal and external combined treatment. The internal treatment mainly focuses on strengthening the spleen， and the external treatment includes retention enema， acupoint application， and other methods. The internal and external combined treatment is mainly based on the internal administration of TCM compounds combined with acupuncture， retention enema， and acupoint stimulation. The study on the mechanism of TCM compounds in preventing and treating colorectal adenoma was mainly explored from the aspects of regulating intestinal flora， regulating cell proliferation immune function， and achieving anti-inflammation. This review summarized the research progress of TCM compounds in the prevention and treatment of colorectal adenoma in recent years and provided a reference for future treatment with TCM.
