Research progress on the prevention and treatment of cardiovascular diseases using traditional Chinese medicine for promoting blood circulation and removing blood stasis by regulating autophagy
- VernacularTitle:活血化瘀类中药通过调控细胞自噬防治心血管疾病的研究进展
- Author:
Xin SUN
1
;
Xiao LIANG
1
;
Yalan LI
1
;
Zhan XIAO
1
;
Wulong WEN
1
;
Weiye ZHANG
1
;
Jing YANG
2
;
Rui WANG
1
Author Information
1. College of Pharmacy，Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. College of Basic Medicine，Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
autophagy;
traditional Chinese medicine;
promoting blood circulation and removing blood stasis;
cardiovascular
- From:
China Pharmacy
2024;35(16):2048-2054
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is mediated by multiple molecules and pathways. In cardiovascular diseases， autophagy can play a role through key signaling pathways such as phosphoinositide 3-kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR）， adenosine monophosphate-activated protein kinase （AMPK）/mTOR， mitogen-activated protein kinases （MAPK）， p53， Wnt/β-catenin， etc. Traditional Chinese medicine （TCM） monomers for promoting blood circulation and removing blood stasis such as hydroxysafflor yellow A， ginsenoside Rb1， salidroside， ligustrin， curcumin， etc.， and TCM prescription and preparations such as Huangqi baoxin decoction， Taohong siwu decoction， Tongxinluo capsule， Shuangshen ningxin capsule， Suxiao jiuxin pills， etc. can regulate autophagy through the above-mentioned key signaling pathways， thereby alleviating the progression of cardiovascular diseases.
