Role of ferroptosis in hepatic ischemia-reperfusion injury
- VernacularTitle:铁死亡在肝缺血再灌注损伤中的作用
- Author:
Jiaxin LIANG
1
;
Baolin XU
1
;
Yu CHENG
1
;
Yong WEI
1
Author Information
- Publication Type:Review
- Keywords: Ferroptosis; Reperfusion Injury; Liver Diseases
- From: Journal of Clinical Hepatology 2024;40(8):1693-1698
- CountryChina
- Language:Chinese
- Abstract: Ferroptosis is a new type of regulatory cell death and is mainly caused by changes in intracellular iron homeostasis due to various inducers， which promotes the occurrence of iron ion-dependent lipid peroxidation， thereby leading to the accumulation of toxic lipid peroxides and finally resulting in cell death. Hepatic ischemia-reperfusion injury is a common and serious complication after liver surgery， with the main mechanisms of anaerobic respiration， mitochondrial injury， oxidative stress response， inflammatory response， calcium overload， and microcirculation dysfunction. This article introduces the concepts and mechanisms of ferroptosis and hepatic ischemia-reperfusion injury and summarizes some related treatment strategies， so as to provide a reference for exploring new treatment methods for hepatic ischemia-reperfusion injury.
