The role of circadian clock-controlled mitochondrial dynamics in nonalcoholic fatty liver disease

VernacularTitle:生物钟调控的线粒体动力学在非酒精性脂肪性肝病中的作用
Author: Ce ZHANG ¹ ; Jiarui MIAO ¹ ; Xu FAN ²
Author Information

1. School of Acupuncture and Massage， Liaoning University of Traditional Chinese Medicine， Shenyang 110000， China
2. School of Integrated Traditional Chinese and Western Medicine， Liaoning University of Traditional Chinese Medicine， Shenyang 110000， China
Publication Type:Review
Keywords: Non-alcoholic Fatty Liver Disease; Biological Clocks; Mitochondrial Dynamics
From: Journal of Clinical Hepatology 2024;40(8):1670-1676
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease （NAFLD） is a disease closely associated with metabolic abnormalities and is currently one of the most common chronic liver diseases. Mitochondria are highly dynamic organelles involved in a variety of metabolic and bioenergetic pathways in the liver， and they respond to environmental changes in a highly dynamic manner through mitochondrial dynamics. The circadian clock is able to modulate mitochondrial dynamics， making it exhibit rhythmic changes. In case of circadian rhythm disorders， mitochondrial dynamics loses rhythmicity， and mitochondria are unable to respond to changing energy demands in different environments， leading to the development and progression of NAFLD. This article summarizes the important role of circadian clock-controlled mitochondrial dynamics in the etiology of NAFLD.