Diagnosis of herb-induced liver injury： Challenges in practice

Yinuo Dong; Yang Zhi; Jieting Tang; Yimin Mao

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Diagnosis of herb-induced liver injury： Challenges in practice

VernacularTitle:中草药相关肝损伤的诊断：实践中的挑战
Author: Yinuo DONG ¹ ; Yang ZHI ¹ ; Jieting TANG ¹ ; Yimin MAO ¹
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1. Division of Gastroenterology and Hepatology， Renji Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai Institute of Digestive Disease， Shanghai Research Center for Diagnosis and Treatment of Fatty Liver Disease， Shanghai 200001， China
Publication Type:Journal Article
Keywords: Drugs， Chinese Herbal; Chemical and Drug Induced Liver Injury; Diagnosis; Causality Assessment; Biomarkers
From: Journal of Clinical Hepatology 2024;40(8):1533-1537
CountryChina
Language:Chinese
Abstract: With the increasingly wide application of herbal medicines and dietary supplements worldwide， herb-induced liver injury （HILI） has become an important etiology of drug-induced liver injury. Due to the diverse manifestations of HILI， the difficulty in medical history collection， and the lack of specific biomarkers， how to identify suspected patients and make a correct diagnosis has become a major challenge in practice. Causality assessment is commonly used in the diagnosis of HILI， but there is still a lack of prospective cohort studies with a large sample size. In addition， further studies are needed to search for the specific biomarkers for the diagnosis of HILI. The diagnosis and differential diagnosis of HILI are challenging， and currently there is still no universally accepted uniform and standard method for the diagnosis of all-cause HILI.