Phenotypic characteristics and toxicological mechanisms of herb-induced liver injury

VernacularTitle:中草药相关肝损伤的表型特征及毒理机制
Author: Tingting HE ¹ ; Zhaofang BAI ¹ ; Jiabo WANG ² ; Xiaohe XIAO ¹
Author Information

1. Senior Department of Hepatology， Department of Traditional Chinese Medicine， the Fifth Medical Center of PLA General Hospital， Beijing 100039， China
2. School of Traditional Chinese Medicine， Capital Medical University， Beijing 100069， China
Publication Type:Journal Article
Keywords: Drugs， Chinese Herbal; Chemical and Drug Induced Liver Injury; Toxicology of Chinese Materia Medica
From: Journal of Clinical Hepatology 2024;40(8):1525-1532
CountryChina
Language:Chinese
Abstract: In order to deal with the problem of the safety of Chinese herbal medicine in a scientific way and further meet the growing health needs of people， it is particularly important to deepen the research on herb-induced liver injury. This article elaborates on the phenotypic characteristics and toxicological mechanisms of herb-induced liver injury and emphasizes that it should not only rely on the previous knowledge of the toxicity of Chinese herbal medicine， but also understand the new types of idiosyncratic toxicity， indirect toxicity， and mixed toxicity， which provide a new perspective for understanding the toxicological mechanisms of herb-induced liver injury and are of great importance to investigate the phenotype and toxicological mechanism of herb-induced liver injury.