The material basis and toxic mechanism of herb-induced liver injury
- VernacularTitle:中草药相关肝损伤的物质基础及其毒性机制
- Author:
Xueying LIU
1
;
Huihui SHI
1
;
Haowen WANG
1
;
Tao YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Drugs， Chinese Herbal; Chemical and Drug Induced Liver Injury; Material Basis
- From: Journal of Clinical Hepatology 2024;40(8):1512-1518
- CountryChina
- Language:Chinese
- Abstract: Herb-induced liver injury （HILI） tends to have complex toxic material basis and toxic mechanism， which greatly affects the safety of traditional Chinese medicine. This article summarizes the main toxic components of Chinese herbal medicine causing liver injury and their mechanism of action. The toxic components of Chinese herbal medicine causing liver injury can be classified into two categories of drug-derived and non-drug-derived toxic components. Drug-derived toxic components mainly include alkaloids， terpenoids， anthraquinones， and phenylpropanoids， and their mechanism of action involves oxidative stress， apoptosis and necrosis， CYP450 enzymes， and genotoxicity. Non-drug-derived toxic components mainly include pesticide residues， sulfur dioxide residues， heavy metals， fungi， and plant growth regulators， and their mechanisms involve oxidative stress， apoptosis， metabolic disorders， and CYP450 enzymes. On this basis， this article further proposes the unsolved problems and research difficulties， in order to promote the basic research on the hepatotoxicity of traditional Chinese medicine.
