Advances in chiral analysis and stereoselective pharmacokinetics of dihydropyridine calcium antagonists

VernacularTitle:二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展
Author: Yixin ZHANG ¹ ; Xinyi GUAN ; Boning WANG ; Jun WEN ; Zhanying HONG
Author Information

1. 海军军医大学药学系,上海 200433
Keywords: Dihydropyridines; Chiral resolution; HPLC; CE; Pharmacokinetics
From: Journal of Pharmaceutical Practice and Service 2024;42(8):319-324
CountryChina
Language:Chinese
Abstract: Chiral drugs are closely related to the safety and effectiveness of drug use.Most dihydropyridine drugs have chiral carbon atoms,which are used as racemes and produce stereoselective disposal characteristics after entering the body,and may affect the safety and effectiveness of drugs.Therefore,based on the chiral resolution and pharmacokinetic characteristics of this class of drugs,the selection rules of chiral HPLC and CE methods and in vivo analysis applications of this class of drugs in recent years were reviewed.The stereoselective pharmacokinetics of this class of drugs were listed and compared.It was found that some of these drugs had obvious differences in stereoselective pharmacokinetics,and the pharmacokinetics and toxicity in vivo were also different.