Effects of the Serum Adiponectin to Tumor Necrosis Factor-alpha (TNF-alpha) Ratio on Carotid Intima-Media Thickness in Newly Diagnosed Type 2 Diabetic Patients.
- Author:
Kwang Youn KIM
1
;
Jung Ae HONG
;
Ha Won HWANG
;
Sun Ho LEE
;
Ju Ri PARK
;
Sung Hoon YU
;
Jun Goo KANG
;
Ohk Hyun RYU
;
Seong Jin LEE
;
Eun Gyung HONG
;
Doo Man KIM
;
Jae Myung YOO
;
Sung Hee IHM
;
Moon Gi CHOI
;
Hyung Joon YOO
;
Chul Sik KIM
Author Information
- Publication Type:Original Article
- Keywords: Diabetes Mellitus; Type 2; Adiponectin; TNF-alpha; Carotid Atherosclerosis; Carotid Intima Media Thickness
- MeSH: Adiponectin*; Adipose Tissue; Atherosclerosis; Cardiovascular Diseases; Carotid Artery Diseases; Carotid Intima-Media Thickness*; Diabetes Mellitus; Follow-Up Studies; Humans; Risk Factors; Tumor Necrosis Factor-alpha*
- From:Journal of Lipid and Atherosclerosis 2015;4(1):7-15
- CountryRepublic of Korea
- Language:Korean
- Abstract: OBJECTIVES: Type 2 diabetes, a leading cause of cardiovascular disease, is well known for its association with accelerated atherosclerosis. Adiponectin and tumor necrosis factor - alpha (TNF-alpha), which are produced and secreted in adipose tissue, have been suggested as predictors for cardiovascular disease. However, little is known about the influence of adiponectin and TNF-alpha ratio on the progression of carotid atherosclerosis in newly diagnosed type 2 diabetic patients. This study was conducted to evaluate the influence of serum adiponectin/TNF-alpha levels on the progression of carotid atherosclerosis. METHODS: One hundred eleven newly diagnosed type 2 diabetes patients were enrolled. Anthropometric and biochemical data including serum adiponectin, TNF-alpha were measured for each participant. Also we measured carotid intima-media thickness (CIMT) at baseline and at 1 year follow-up (n=81). We finally examined the relationship among serum adiponectin over TNF-alpha levels (ADPN/TNF-alpha), baseline CIMT, and progression of CIMT at 1 year. RESULTS: ADPN/TNF-alpha negatively correlated with baseline CIMT (r=-0.231, p=0.025). Moreover, progression of CIMT was significant at 1 year (0.011+/-0.138 mm). There was a negative correlation between ADPN/TNF-alpha and progression of CIMT at 1 year (r=-0.172, p=0.038). In multiple regression analysis, age and HbA1c were found to be independent risk factors for baseline CIMT. However, only HbA1c was an independent risk factor for the progression of CIMT. CONCLUSION: ADPN/TNF-alpha was negatively associated with baseline CIMT and the progression of CIMT at 1 year. Overall glycemic control is the most important factor in the progression of CIMT in patients with type 2 diabetes.
